Secretin’s story holds an important lesson that extends far beyond autism.
Many, if not the majority of families ‘have a child with Autism Spectrum Disorder (ASD)’later Diet and nutritional approaches as components of therapy. Estimated use of alternative therapies Domain 28 to 95 percent, with special diets or supplements being the most common approach. Why is it so prevalent? my video Alternative therapies for autism explores the case.
“Probably the acting When suspected or distrustful of standard medical practices, a desire not to ‘numb’ their children or a desire to seek curative treatment out of frustration with the shortcomings of conventional medical interventions, therapies based on nutritional interventions appeal to parents of children with autism. A safer, natural, and holistic approach to treating their children’ – but it may also simply be because the drugs aren’t working.
“Pharmacological interventions in ASD are mainly Aims To reduce commonly associated symptoms, including inattention, impulsivity, hyperactivity, compulsion, anxiety, sleep disturbances, irritability, self-harm, and aggressiveness”—calming them and helping them sleep—but having no effect on “the core symptoms of autism spectrum disorder, such as Social withdrawal and abnormal behaviors. Only two drugs were used agreed by the US Food and Drug Administration for the treatment of autism…and both target the associated behavior problem, irritability, rather than underlying deficiencies in social skills and repetitive behaviour. Both drugs also have significant side effects, including weight gain and sedation. Therefore, it is not surprising that parents are seeking complementary and alternative medicine (CAM) therapies to try to help their affected children.” OK, but do the alternatives work better?
In the alternative medicine literature, you will We see Lots of this kind of situation: Schmemidin Guide! As long as the treatment is not harmful, why not give it a try? Or go so far as to suggest trying a cure even if the evidence is stacked against it, because — who knows? Your children may be the exception. I sympathize with this thinking. “Unfortunately there be Many are unscrupulous charlatans eager to take advantage of desperate parents to try anything that seems to help their autistic children. we [researchers] Receive several emails per week from practitioners who offer the “treatment” for autism (often at a “low and low” price of $299). We are often intimidated by how these emails use guilt and cunning to encourage families to try these untested remedies because “If you really loved your child, wouldn’t you want to spare no effort without turning him on?”
When challenged, “Many practitioners of these supposed treatments will say things like ‘I know it works,’ or ‘I’ve seen it work’, or ‘I don’t want to spend time and money testing it when I can help kids right away.'” we [researchers] Urging parents to run, not walk, and to stay away from any treatment claiming to be too good for the science.” Indeed, “all treatments must be subject to the rigors of well-designed, double-blind, placebo-controlled clinical trials.” Our children do not deserve Less than that.
parents attempt In any case, often without telling their doctors, “citing an unwillingness to consider the potential benefits [of alternatives] Among doctors, “which I think Originates Because we have been burned many times before. “High-profile examples of ineffective or dangerous CAM therapies have led to a general distrust and aversion to anything believed to be out of the box.”
Takes Secretin’s Story: “Improved social and language skills”—ie, improvement in core autism symptoms—“after administration of secretin in patients with autism spectrum disorders.” Secretin is an intestinal hormone that is involved in digestion and is used in a diagnostic test of pancreatic function. The researchers just happened to run this test on some children who had just developed autism, and to their surprise, within weeks of taking the test, there was “a significant improvement in their behaviour, manifested by improved eye contact, alertness, and an expansion of expressive language”.
This is understandable Effects Media “madness”, and parents scrambled to find things, “resulting in a black market for drugs…what makes a TV show interesting may not, of course, be the same as what makes good science.” You have to test it.
A randomized controlled trial was conducted on the effect of serine on children with autism he did, and “No significant effects were found”. The study used porcine secretin – swine hormones. Could human keratin work better? No, apparently not. there I was “Don’t take advantage” of human secrecy, too. But, as you can see below and at 4:27 in my country videothe data appeared at first show This secret worked perfectly. One shot of the two secrets, autistic behaviors fall within days! The same thing happened when the placebo was injected, which is why we do placebo-controlled studies.
“Extensive trading [those] Anecdotal reports of secretin’s benefits in the treatment of autism may have raised expectations among parents and caregivers and their bias toward perceiving improvement,” explaining the effects of placebo injections. In this way, “ineffective treatments for autism are often promoted and widely accepted” even if they are not There was no evidence to support it, evidenced by the fact that “most fathers [in the study] She remained interested in secretin as a form of treatment for autism in their children even after telling us about it [the researchers] No evidence of benefit was found.” They were told it didn’t work, but they couldn’t give up hope. So, the autism community continued to pressure and cling to the idea that it was fair. she has for work.
Finally, 16 randomized controlled trials were performed Procedure Involving more than 900 children, no evidence of benefit was found. “There are no studies open Significantly greater improvements in measures of language, cognition, or symptoms of autism when compared to placebo.”
“In the absence of effective and affordable treatments for autism, parents of children with the disorder be Highly vulnerable to exorbitant claims of potential cures.” In the case of secretin, it was like a perfect storm of myth-mongering factors, which “prompted thousands of parents to buy secretin, often at hundreds or even thousands of dollars per dose.” The Secretin Story exemplifies the importance of subjecting proposed treatments to scientific scrutiny as opposed to accepting anecdotal reports as evidence of efficacy.”
Sometimes alternative approaches work, sometimes they don’t. You don’t know until you put them to the test.